Metabolomic profiling of early inactive hepatic alveolar and cystic echinococcosisArticle Published on 2023-06-012023-06-22 Journal: Acta tropica [Category] 조류인플루엔자, [키워드] alveolar Biomarkers Cysts Echinococcosis hepatic Metabolomic profiling. [DOI] 10.1016/j.actatropica.2023.106875 PMC 바로가기
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike proteinArticle Published on 2022-12-012022-11-15 Journal: Medical molecular morphology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation alveolar Analysis can be used CD68 Cell cells characteristics of patient chromatin COVID-19 cytological cytoplasmic definitive diagnosis double infection epithelial evaluated exclusion expression Herpe herpes simplex herpes simplex virus immunocytochemistry Inclusion infected cell Infection intranuclear multinuclear nuclear nuclei Patient performed pneumocyte positive protein A SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 simplex specimen sputum Sputum sample Sputum. staining These cells Treatment viral infection virus [DOI] 10.1007/s00795-022-00326-9 PMC 바로가기
Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Antioxidant, Anti-inflammatory, and Immunomodulatory Roles of Nonvitamin Antioxidants in Anti-SARS-CoV-2 TherapyArticle Published on 2022-10-132022-11-15 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 receptor Activation activities alleviate Alleviating alveolar antioxidant antiviral role conformational change COVID-19 Cytokine storm Dipeptidyl peptidase 4 Direct dosage Endothelium favor furin Helicase host receptor hyperinflammation Illness severity immunogenic Inflammatory Inflammatory responses influences membranes Organ failure oxidative stress Papain-like protease pathology pathway protease reactive oxygen specy Receptor binding domain Replication risk RNA-dependent RNA polymerase role serine 2 the spike protein transmembrane vicious cycle viral spike protein [DOI] 10.1021/acs.jmedchem.2c01134 PMC 바로가기
Pulmonary Involvement in SARS-CoV-2 Infection Estimates Myocardial Injury RiskArticle Published on 2022-10-112022-11-15 Journal: Medicina [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome Admission age Alpha alveolar ambient biochemical biochemical marker Biomarker C reactive protein can be used cardiac injury chest scan Computerized tomography consecutive patients consolidation coronavirus correlated correlation COVID-19 COVID-19 complications COVID-19 patient COVID-19 risk factors CRP CT scan Diastolic blood pressure dysfunction elevated estimate Factor Factors fibrinogen group Hospitalization IL-6 Infection Inflammatory marker Injury interleukin-6 interlobular septal thickening interstitial Involvement lactate dehydrogenase LDH lesion lung Lung disease lung involvement material multisystemic myocardial injury myocardial injury. myocardial involvement Myoglobin Necrosis non-specific NT-proBNP objective Observational cohort study occurred parameters pathology Patient Patient care performed peripheral oxygen saturation Pneumonia pulmonary pulmonary involvement pulmonary lobe radiological Registered respiratory rate respiratory rates Result risk routine SARS-CoV-2 SARS-COV-2 infection Serum ferritin severity Sex significant difference Systolic blood pressure the disease the patient the study group TnI [DOI] 10.3390/medicina58101436 PMC 바로가기
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cellsArticle Published on 2022-09-212022-11-15 Journal: eLife [Category] 바이오마커, 유전자 메커니즘, [키워드] alveolar alveolar epithelial cell alveolar epithelium alveolar regeneration Basal cell basal cells Biomarkers cause Cell Cell Biology Complete COVID-19 ectopic epithelial epithelial cell function IMPROVE increase independent Infection lineages lung lung parenchyma lung regeneration Lungs mechanism mice mouse mouse model Notch other organs proliferate promote promoted regenerative regenerative medicine regulate significantly stem cells suggested suppressed Tamoxifen tuft cell tuft cells viral infection Viral infection. Wnt [DOI] 10.7554/eLife.78217 PMC 바로가기
SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy PathogenesisArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 acute respiratory distress alveolar angiotensin-converting enzyme 2 binding blocked Blood coagulation Capillaries cell types cellular co-culture Coagulopathy communication Contact COVID-19 COVID-19 patient Delta Disease progression drug DTNB endothelial Endothelial cell endotheliopathy Evidence Express expression extrinsic pathway Factor Factor-V fibrinogen functional groups had no Human human lung human lung endothelial cells humans induce infect inhibited inhibitor interactions investigated leukocyte mechanism Microvascular thrombosis neutrophil Neutrophils Pathogenesis pathway Patient potential mechanisms prevented Protein pulmonary complication Pulmonary endothelium recombinant S-protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 variant SARS-CoV-2 virion secretion severe lung injury significantly increased spike syndrome target cell TFPI therapeutic strategy thrombin thrombomodulin thrombosis tissue Tissue factor. Transcriptional upregulation vascular endothelial cell vessel Wuhan [DOI] 10.3390/ijms231810436 PMC 바로가기
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mRNA vaccines. mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기